The OVERALL GOAL of this work is to accelerate the development of improved rehabilitation
approaches for people with multiple sclerosis (MS) by characterizing the distinct
functional effects and mechanistic underpinnings of task-oriented versus generalized resistance and
aerobic exercise.

​

Walking is one of the most commonly disrupted and valued motor functions among people with MS. Virtually all individuals with MS experience walking impairments. These deficits in walking function have negative impacts on performance of instrumental activities of daily living, socioeconomic status, employment, and health-related quality of life in people with MS.

​

Exercise is beneficial for people with MS. However, the "key ingredients" required for exercise to optimally improve walking function for people with MS remain largely unknown. Additionally, optimal exercise strategies to maximize positive change in the central nervous system (CNS) in people with MS are not well understood to date.

​

The proposed research is designed to address the critical need for development of targeted exercise strategies that maximize functional benefits and drive supporting changes in the central nervous system in people with MS.